Headless commerce for B2B wholesalers helps separate the customer-facing storefront from legacy ERP systems, creating faster and more flexible digital buying experiences. This guide explains how APIs connect commerce platforms with ERP, PIM, CRM, OMS, WMS, payment, tax, and shipping systems while allowing businesses to modernize their storefront without replacing a working ERP. Learn how headless B2B commerce supports customer-specific pricing, inventory visibility, bulk ordering, self-service purchasing, and complex wholesale workflows while reducing dependence on legacy systems. Explore the architecture, integration approach, implementation phases, and key considerations for building a scalable B2B commerce experience.